please, explain . Question 36 3 out of 6 points . dicate whether each of the fol

Question

please, explain

. Question 36 3 out of 6 points . dicate whether each of the following statements applies to nuclear import (NID. mitochondrial import (M), both (B), or neither (N). Use only NI, M. B, or N for your answers. The polypeptide to be transported into its organelle has a specific stretch of amino acids that targets it to the organelle [al The signal sequence at the N-terminus is removed by a peptidase Ibl The signal sequence is bound by a receptor on the organelle's outer membrane lel ATP hydrolysis is involved in translocation [d) GTP hydrolysis is involved in translocation lel Chaperones are involved in the translocation process [n Answer Specified Answer for. a Specified Answer for: B M Specified Answer for: c NI Specified Answer for: M Specified Answer for: e M Specified Answer for:f B

Explanation / Answer

Nuclear import of proteins involves the presence of nuclear localization signals (rich in lysine and arginine) which are bound by receptors on outer membrane. Chaperones are involved in the nuclear targetting to avid any misfolding of proteins. Therfore sentences a, c and f are true for nuclear import.

A protein destined to be imported into mitochondria is normally synthesized with a transient N-terminal extension that functions as a targeting signal which is removed by peptidase as opposed to nuclear proteins. Both ATP and GTP hydrolysis are required for mitochondrial import of proteins. For those mitochondrial precursors prone to misfolding or aggregation, cytosolic chaperones are available to prolong their ‘import competence. therefore sentences a, b, d, e and f are correct for mitochondrial import of proteins.

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