1. Anti-dinitrophenol (DNP) antibodies produced in strain A mouse are injected i

Question

1.   Anti-dinitrophenol (DNP) antibodies produced in strain A mouse are injected into strain B mouse.   a. Isotypic    b. allotypic     c. idiotypic

2. Anti-bovine gamma globulin (BGG) mAbs from a Strain A mouse are injected into another Strain A mouse. a. Isotypic      b. allotypic   c. idiotypic

3. Anti-BGG antibodies produced in Strain A mouse are injected into a rabbit. a. Isotypic      b. allotypic   c. idiotypic

4.  Anti-BGG antibodies from Strain A mouse are injected into the same mouse   a. Isotypic      b. allotypic   c. idiotypic

5. A protein with a molecular wt of 30,000 Da, and another protein with a MW of 150,000 are predicted to be equally immunogenic (true or false)

Explanation / Answer

1. Allotypic antibodies: allotypic antibodies produced within the same species of organism due to chamges in the constant region of either the heavy chain or the light chain within the same class of the antibody.

2. Allotypic antibody: It is acting with in the strain so it comes under allotypic anty body

3. Isotypic antibody: These antibodies nothing but the classes of antibodies. The five antibodies obtained due to changes in the Fc reagion of the antibodies. The all organisms in the same species will produce same antibodies.

4.Idiotypic antibodies: These are highly specific these or produced due to changes in the variable region. So they are spefic with in the individuals.

5. False: The molecular size/weight of the protein are known to influence the immunogenecity. Higher molicular size compounds likely to be more immunogenic than the smallar.

2.

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