Hi there, I am looking for some help with my toxicology study guide questions 14

Question

Hi there, I am looking for some help with my toxicology study guide questions

14. If a NCE causes QT interval prolongation in an in vitro study, this indicates high probability that the NCE will cause _______ in vivo.

A) Cardiotoxicity

B) Reproductive toxicity

C) Respiratory toxicity

D) Genotoxicity

15. If a drug induces any isoform of CYP450, that drug cannot be approved by the FDA.

A) True

B) False

16. Toxicity of the reproductive organs themselves is called:

A) Teratogenesis

B) Cancer

C) Offspring toxicity

D) Reproductive toxicity

17. Times during development when organ systems are most susceptible to damage are called:

A) Formation periods

B) Manifestations

C) Critical periods

D) Teratogen times

18. Low exposure levels to methylmercury preferentially targets the developing fetus, in comparison to the relative lack of effects in the mother. This is a classic example of which of Wilson’s six principles?

A) Specificity

B) Selectivity

C) Dose-response effect

D) Genetic influence

19. The organ system susceptible to damage for the longest period of time during development is the:

A) Nervous system

B) Heart

C) Palate

D) Arms

20. The drug originally used as a morning sickness therapeutic from the mid-1950s through the early 1960s, that caused birth defects including Amelia (lack of limbs), is:

A) Thalidomide

B) Accutane

C) Diethylstilbestrol

D) Methylmercury

Explanation / Answer

20) The drug that caused birth defects like Amelia is Thalidomide.

18) Low exposure levels to methylmercury preferentially target the developing fetus, in comparison to the relative lack of effects in the mother. This is a classic example of which of Wilson’s six principles of Dose-response Effect.

17) Times during development when organ systems are most susceptible to damage are called: Teratogen times

16) Toxicity of the reproductive organs is called: Reproductive toxicity

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