6. A certain pre-mRNA has 5 splice sites Splice sites During processing to a mat

Question

6. A certain pre-mRNA has 5 splice sites Splice sites During processing to a mature mRNA, the pre-mRNA can be cut at 0 or 2 splice sites. a. How many possible mature mRNAs can be formed? b. The likelihood of cutting the pre-mRNA at a given splice site can be modeled by a binomial distribution where the probability of cutting is p0.2. i. If the spliceosome attempts to cut each splice site one time, what is the mean number of cuts the spliceosome makes? What is the standard deviation? ii What is the probability that 0 cuts occur if the spliceosome attempts to cut each splice site one time? i What is the probability that 2 cuts occur if the spliceosome attempts to cut each splice site one time? What isoform class of the mature mRNA (0 cuts or 2 cuts) is the most common based on abundance and cutting probabilities? c.

Explanation / Answer

Mature mRna is eukaryotic rna that has been processed and spliced and used for translation in the protein synthesis.

a) four mature mRna can be formed

b) i p(X=x) =nCxpxqn-x

mean =np

5*0.2=1

SD=npq1/2

np=1

q=1-p=1-0.2=0.8

=0.8944

ii) 0.8

iii)0.032

c) 0 cuts

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