AT&T; LTE 6:48 PM × Week 3 problem set-BISC336.pdf Problem Set 3 Due 2/13 1) Bas

Question

AT&T; LTE 6:48 PM × Week 3 problem set-BISC336.pdf Problem Set 3 Due 2/13 1) Based on the above pedigree Why is this unlikely to be a mutation in mitochondrial DNA or matemal effect? 2) Aspontaneous mutation occurs in one of the copies of MT-TK, a gene found in mitochondrial DNA MT-TK generates mitochondrial function. tRNA required to make proteins for a. How can this mutation become deleterious? b. In which parent and in which cells must this spontaneous mutation occur for it to be inhenited? (hint what happens if the mutation occurs in the heart) 3) In order to map the distance between two linked genes, CC DD individuals were crossed to cc dd individuals. The F1 generation was then testcrossed to cc dd individuals. The resulting individuals had the following genotypes: Open With Print

Explanation / Answer

this mutation is not mitochondrial or maternal effect because as closely eximine the pedigree, it has a inheritance pattern of X- linked recessive inretance. when both the mutated allele is present the female become affected and male is always become affected. there is also a chance of female being carrier of that mutation which inherent mutation in progeny (if progeny is male than it is affected).

as indicated no.4 female individual in generation III who is married to normal male, she may be carrier or normal. if she is carrier than offspring will be, male= affected and female= 50% carrier and 50% nomral,

if she is normal than all the individual in progeny are normal (i.e male and female both).

2a. MT-TK is mitochondial mutation, mutation in this gene leads to abnormal developement of t-RNA. mutation in this gene associated with maternally inherited diabetes and deafness. mutations in MT-TK is also associated with myoclonic epilepsy. as this deleterious effect is prominent in males because it is maternally inherited but remain normal or carrier for females.

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