Question 8 (1 point) Assume the that the DNA is in the B-form with a helix diame
ID: 193551 • Letter: Q
Question
Question 8 (1 point)
Assume the that the DNA is in the B-form with a helix diameter of 23 Å, 3.4 Å between each base, and 10.5 base pairs per turn of the helix. What is the linking number for a 3,570 bp closed circular duplex relaxed DNA?
Question 8 options:
340
155
1050
0
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Question 9 (1 point)
How would the topology of a closed circular DNA molecule change if its linking number was lowered by 4 and the twist did not change?
Question 9 options:
The molecule would have 3 positive supercoils and 1 negative supercoil
The molecule would now have 4 negative supercoils.
The molecule would now have 4 positive supercoils.
The molecule would have 2 positive supercoils and 4 negative supercoils
The molecule would have 1 positive supercoil and 3 negative supercoils
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Question 10 (1 point)
Which of the following structural changes is NOT more favorable when a DNA molecule is negatively supercoiled?
Question 10 options:
Separation of the complementary strands of DNA
Formation of Z-DNA
Formation of plectonemic coils
Phosphodiester backbone breakage
Formation of Cruciform structures
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340
155
1050
0
Explanation / Answer
8.
Option A is correct.
Linking number = 3570/10.5 = 340
9.
Option C is correct.
If the linking number is lowered by 4 without affecting the twist, the molecule would now contain four positive supercoils.
10.
Option D is correct.
Phosphodiester backbone breakage is not more favourable when a DNA molecule is negatively super coiled.
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