1. For each of the following statements, tell whether it is more correct for MHC
ID: 193430 • Letter: 1
Question
1. For each of the following statements, tell whether it is more correct for MHC class I, MHC class II, or equally true for both. (you can just put class I, class II, or both) (
a) Expressed by all nucleated cells of the body
(b) Represented by HLA-DR, DQ, and DP in humans
(c) Can generate hybrid molecules that are not present in either of the parents of the individual, therefore allowing different immune responses
(d) Recognized by T cells expressing the CD8 cell surface antigen
(e) Differ widely among the human population because there are many different alleles of the genes
2. For each of the responses listed below, tell whether it is more representative of macrophages, neutrophils, or both.
(a) Produces interleukin 1 and tumor necrosis factor alpha
(b) Can be both pro-inflammatory and anti-inflammatory depending on cytokines produced
(c) Phagocytosis and killing of microbes
(d) Traps microbes by releasing the cellular contents as “nets”
(e) Cytoplasm contains granules that can be observed microscopically
3- For each of the statements below, indicate which antibody isotype it best describes: IgG, IgM, IgA, IgD, or IgE.
(a) Low affinity antibody that dominates primary immune responses.
(b) Found only on mature B cells, not secreted in any form. (
c) Found mainly in the mucosal tissues and secretions, not so much in blood.
(d) Binds to receptors on mast cells and triggers allergic reactions. (
e) The most abundant serum antibody isotype.
Explanation / Answer
1) a) Expressed by all nucleated cells of the body- MHC I
(b) Represented by HLA-DR, DQ, and DP in humans - MHC II
(c) Can generate hybrid molecules that are not present in either of the parents of the individual, therefore allowing different immune responses - Both
(d) Recognized by T cells expressing the CD8 cell surface antigen - MHC I
(e) Differ widely among the human population because there are many different alleles of the genes -both
2.
(a) Produces interleukin 1 and tumor necrosis factor alpha - both
(b) Can be both pro-inflammatory and anti-inflammatory depending on cytokines produced - Macrophage
(c) Phagocytosis and killing of microbes - macrophage
(d) Traps microbes by releasing the cellular contents as “nets” - Neutrophils (net full form is neutrophils extracellular traps)
(e) Cytoplasm contains granules that can be observed microscopically - neutrophils(this WBC comes under granulocyte cells)
3-
(a) Low-affinity antibody that dominates primary immune responses. (IgM)
(b) Found only on mature B cells, not secreted in any form. (IgD)
c) Found mainly in the mucosal tissues and secretions, not so much in blood. (IgA)
(d) Binds to receptors on mast cells and triggers allergic reactions. (IgE)
e) The most abundant serum antibody isotype.(IgG)
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