Beclin -1 Can act as a haploinsufficient tumor suppressor Promotes autophagy Is

Question

Beclin -1 Can act as a haploinsufficient tumor suppressor Promotes autophagy Is a BH3-domain-containing protein Can be found in Bcl-2 All of the above. Is the answer-All of the above?
Beclin -1 Can act as a haploinsufficient tumor suppressor Promotes autophagy Is a BH3-domain-containing protein Can be found in Bcl-2 All of the above. Is the answer-All of the above?
Beclin -1 Can act as a haploinsufficient tumor suppressor Promotes autophagy Is a BH3-domain-containing protein Can be found in Bcl-2 All of the above. Is the answer-All of the above?

Explanation / Answer

Beclin-1 plays a crucial role in oncogenesis and neurodegeneration. It has been well established that Inhibition of beclin by miR-30d suppresses autophagy. Therefore, Beclin-1 promotes autophagy. Moreover, it was the first protein which showed haploinsufficient tumor suppression. Beclin 1 possesses BH3 domain (a.a. 114–123), so it is a BH3 domain containing protein. Both Beclin-1 and BCL-2 homology 3 (BH3) domain-containing peptides obtained from proapoptotic BCL-2 family proteins. Therefore, Beclin-1 can be found in Bcl-2.

Yes, the answer is all of the above.

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