3. What is the function of the adaptor complex in clathrin mediated transport? 1

Question

3. What is the function of the adaptor complex in clathrin mediated transport? 1 point) O It induces membrane curvature It helps pinch off the vesicle it recruits the cargo to the site of vesicle budding through specificinteraction with signals in the cytosolic tail of cargo receptors O It recruits the cargo into the site of vesicle budding through specific interaction with signals in the exoplasmic tail of cargo receptors O It induces the uptake of all transmembrane proteins in the plasma membrane 4 Which sorting signal has to be present on a protein in order to be sorted into multi-vesicular bodies? 1 point O N-terminal hydrophobic sequence Amphiphatic helix Stretches of positively charged amino acids O Mono-ubiquitin O poly-ubiquitin

Explanation / Answer

1.The function of adaptor complex in Cathrine mediated transport it recruit the cargo into the site of vesicle budding though specific interaction with singnel in the Cytosolic tail of cargo receptor.

Clathrin adaptor proteins, also known asadaptins, are vesicular transport adaptor proteins associated with clathrin.Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location to another.These complexes concentrate the correct cargo molecules in vesicles that bud or extrude off of one organelle and travel to another location, where the cargo is delivered.The association between adaptins and clathrin are important for vesicular cargo selection and transporting.Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.

2.The multivesicular body (MVB) pathway is responsible for both the biosynthetic delivery of lysosomal hydrolases and the downregulation of numerous activated cell surface receptors which are degraded in the lysosome. We demonstrate that ubiquitination serves as a signal for sorting into the MVB pathway.

Mono ubiquitin sorting single present on a protein in order to be sorted into multi vesiculer bodies.

The multivesicular body (MVB) pathway is responsible for both the biosynthetic delivery of lysosomal hydrolases and the downregulation of numerous activated cell surface receptors which are degraded in the lysosome. Ubiquitination serves as a signal for sorting into the MVB pathway.

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