23. The mutation the causes Tay-Sachs disease, a autosomal recessive neurodegene

Question

23. The mutation the causes Tay-Sachs disease, a autosomal recessive neurodegenerative disease that leads to death usually before the age of 5 years has remained in human populations for many hundreds of generations. Please explain why this mutation persists in humarn populations despite its huge selective disadvantage. 24. What are transcription factors? Why are transcription factors often popular drug targets? Can you describe one of the concerns in using transcription factors as drug targets?

Explanation / Answer

please find the answer of one question only 24

answer of 24 question

Tanscription factor

A transcription factor (TF) or sequence-specific DNA-binding factor is a protein that maintain the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

Transcription factor as a Popular drug targets

Example use as target drugs as transcption factor

Cancer

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