please answer all parts of the single question 1. The pedigree below shows the p
ID: 188308 • Letter: P
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please answer all parts of the single question
1. The pedigree below shows the pattern of inheritance of myopia (nearsightedness) within a human family. This trait is relatively common refractive error of the eye, and it has become increasingly prevalent: a recent study by the National Eye Institute (NE) shows the prevalenceof myopia grew from 25% of the U.S. population (ages 12 to 54) in early 70s, to 41.6% in 1999-2004. The exact cause for this increase in nearsightedness among Americans is unknown and eye doctors suspect correlation between eye fatigue from computer and cellphone use and other extended near-vision tasks, coupled w genetic predisposition. ith a What is the most likely mode of inheritance for this trait based on the above pedigree? Why? (1 pt) a. What is the probability that the first child (represented by a diamond) of individualsIlI-3 and III-4 will be affected by this trait? (1 pt) b. c. If IlI-3 and Ill-4 have three children, what is the probability that none of them will be affected? (1 pt) d. The first child of IlI-3 and Ill-4 turns out to be unaffected. Given that, what is the probability that their next child will be affected? (2 pts) e. The second child of IlI-3 and Ill4 turns out to be affected. Given that, what is the probability that their next child will be affected as well? (1 pt)Explanation / Answer
a.
The given pedigree represents autosomal recessive inheritance pattern.
Reason: Unaffected parents have affected progeny.
b.
III-3 is a carrier because his mother is affected.
The probability for III-3 to be carrier = 100% = 1
The probability for III-4 to be carrier = 2/3
The probability for their kid to be affected = 1 X 2/3 X 1/4 = 0.166 = 16.6%
c.
The probability for the first child to be affected = 16.6%
The probability for the first child to be unaffected = 100 - 16.6% = 83.4% = 0.834
The probability that all three kids to be unaffected = 0.834 X 0.834 X 0.834 = 0.58 = 58%
d.
The probability of acquiring an allele (be it WT or mutant) does not change with the kid number as each of them are independent and random event.
= 16.6%
e.
The probability of acquiring an allele (be it WT or mutant) does not change with the kid number as each of them are independent and random event.
= 16.6%
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