You are screening three new pesticides for potential mutagenicity using the Ames

Question

You are screening three new pesticides for potential mutagenicity using the Ames test. Two his- strains resulting from either a frameshift or a transition mutation were used and produced the following results (number of revertant colonies):

Transition Mutant Control (no chemical)

Transition Mutant + Chemical

Framshift Mutant Control (no chemical)

What type of mutations, if any, do the three pesticides induce? Be very clear and specific...brief answers will receive little to no credit. You must show and explain all work to receive credit.

Strain 1

Transition Mutant Control (no chemical)

Transition Mutant + Chemical

Transition Mutant + Chemical + Rat Liver Enzymes Pesticide#1 21 180 19 Pesticide#2 18 19 17 Pesticide#3 25 265 270

Explanation / Answer

Answer:

Pesticide 1:

This one causes transition mutation. Liver enzymes convert it into non-mutagen. Does not cause frameshift mutations.

Pesticide 2:

This one does not cause transition mutations. Liver enzymes convert it into a frameshift mutagen.

Pesticide 3:

This one causes transition mutations. Liver enzymes have no effect on mutagenicity. Does not cause frameshift mutations.

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