A person suffers from a genetically-based disorder resulting in MHC Class II (ma

Question

A person suffers from a genetically-based disorder resulting in MHC Class II (major histocompatibility complex II) deficiency (has drastically fewer MHC Class II molecules). This person has recurrent bacterial and viral infections. Which of the following deficencies in immune function does this individual particularly have?

a) A reduced ability of cytotoxic T cells to bind to cells infected with the virus

b) A reduced ability of macrophages to phagocytoze bacteria and viruses in the extra-cellular fluid

c) A reduced ability of helper T cells to bind to antigen-presenting dendritic cells

d) A reduced ability of B cells to bind to bacteria or viruses

e) A reduced ability of cytotoxic T cells to bind to antigen-presenting dendritic cells

Please explain which answer is correct and why it is the correct answer. Thank you!

Explanation / Answer

If a person suffers from a genetically- based disorder resulting in MHC class-II deficiency, he is most likely to have recurrent bacterial and viral infections.

Class MHC-II molecules are present only on the surface of antigen presenting cells, in addition to class MHC- II molecules. They present the antigens to TH cells for cell mediated or humoral immunity.

The antigen presenting cells include

Therefore, if the person suffers from a genetically- based disorder resulting in MHC class- II deficiency, it will result in reduced ability of helper T cells to bind to antigen- presenting dendritic cells.

Therefore, option C is correct.

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