You are studying a protein that has two transmembrane domains. The spacing of th

Question

You are studying a protein that has two transmembrane domains. The spacing of the transmembrane domains is shown as, gray boxes in the Figure. The C-terminal domain of the protein is cytoplasmic. Is the N-terminal domain of the protein cytoplasmic or extracellular? Why? Where do you expect to find the N-terminal domain located as the protein is shuttled in a transport vesicle to the plasma membrane? Your friend discovers that this protein is glycosylated. What information did she use to determine the protein is likely to be glycosylated (all she had available was a text file of the amino acid sequence you sent her for study)? Which region of this protein is most likely to be glycosylated? Explain. How could you modify the protein so that the orientation of the C-terminal domain is extracellular, rather than cytoplasmic? Would this change to the protein affect your answer in part C? If so, how?

Explanation / Answer

As the above mentioned protein is a transmembrane protein, it is possible that the N-terminal of the protein chain is located away from the cytoplasm or extracellular. If the N-terminal is located in the extracellular part, it can function as a ligand or receptor molecule for the cell.

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