You are studying a protein that resides in the plasma membrane. The shaded regio

Question

You are studying a protein that resides in the plasma membrane. The shaded regions below represent transmembrane regions and the numbered lines represent regions that are either in the cytoplasm or the extracellular space. You have the additional information about this protein that numbered segments 2 and 4 have N - linked oligosaccharides. Draw the topology of this protein as it is inserted into the membrane. Be sure to label the cytoplasmic and extracellular sides of your membrane and also both the amino and carboxy termini.

Explanation / Answer

Answer: Topology (simply draw it out following these locations): N-terminus: Cytoplasmic side of membrane Region 1: Cytoplasmic side of membrane Region A: Transmembrane region going across the membrane Region 2: Extracellular side of membrane Region B: Transmembrane region going across the membrane Region 3: Cytoplasmic side of membrane Region C: Transmembrane region going across the membrane Region 4: Extracellular side of membrane C-Terminus: Extracellular side of membrane N-linked oligosaccharides are found on the extracellular surface of cells.

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