DNA evidence links Fred Weasley to a crime, but he claims that his identical twi
ID: 179430 • Letter: D
Question
DNA evidence links Fred Weasley to a crime, but he claims that his identical twin, George Weasley, is the perpetrator. George weasley maintains his innocence and donates a chromatin sample to clear his name. Describe 2 properties forensic scientists could look for in the chromatin to distinguish between the twins. DNA evidence links Fred Weasley to a crime, but he claims that his identical twin, George Weasley, is the perpetrator. George weasley maintains his innocence and donates a chromatin sample to clear his name. Describe 2 properties forensic scientists could look for in the chromatin to distinguish between the twins.Explanation / Answer
DNA evidence links Fred Weasley to a crime, but he claims that his identical twin, George Weasley, is the perpetrator. George weasley maintains his innocence and donates a chromatin sample to clear his name. Describe 2 properties forensic scientists could look for in the chromatin to distinguish between the twins.
Answer.
Although the two are identical twins, there would have been differences in the lifestyles of the twins. Our DNA can be modified due to our lifestyle. Such changes to the DNA due to change in lifestyle are called epigenetic changes. The epigenetic change occurs when a methyl group attaches to a gene and modifies the way it is expressed. Epigenetic changes are caused by the influence of a person’s environment, life style and disease.
To do so,
Take mouth swabs from the twins, extract the DNA from each sample, characterization of DNA methylation by bisulfate treatment followed by pyrosequencing.
if the sequences are different, then the melting temperature should be different.
Normally people carry two copies of every gene, one from each parent. There are however regions in the genome of twins which deviate from the two copy rule. These regions have copy number variants that can be between zeroz and 14 copies of a gene. Such variation is natural and it accumulates with age in everyone.
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