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In RNA induced gene silencing, how do the silencing processes begin and what maj

ID: 178258 • Letter: I

Question

In RNA induced gene silencing, how do the silencing processes begin and what major components participate? Select all answers that apply.

Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.

The RISC complex, guided by single-stranded RNA, can silence gene expression by affecting either mRNA stability or translation.

siRNA molecules are derived from single-stranded RNAs that are transcribed from the cell's own genome.

The RITS complex, guided by single-stranded RNA, recruits chromatin remodeling proteins that can repress transcription.

The Dicer complex can cleave both siRNA and miRNA precursors into siRNAs and miRNAs.

a.

Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.

b.

The RISC complex, guided by single-stranded RNA, can silence gene expression by affecting either mRNA stability or translation.

c.

siRNA molecules are derived from single-stranded RNAs that are transcribed from the cell's own genome.

d.

The RITS complex, guided by single-stranded RNA, recruits chromatin remodeling proteins that can repress transcription.

e.

The Dicer complex can cleave both siRNA and miRNA precursors into siRNAs and miRNAs.

Explanation / Answer

Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.

a.

Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.

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