There is the difference between muscle and liver cells where the calcium it comi

Question

There is the difference between muscle and liver cells where the calcium it coming from In muscle cells. Ca 2 + that completes activation of GPK is coming through the and in the liver cells from after IP3 binding In summary, there are many steps in the adrenergic receptor pathway 3nd they proside amplification of the signal Looking at the graph on the right. Circle 2 steps in beta adrenergic signaling cascade that provide amplification of epinephrine action Activation of G protein by epinephrine receptor Activation of adenylyl cyclase by G protein (not shown) production of cAMP by adenylyl cyclase Activation of PKA Activation of GPK by PKA Activation of GP by GPK The final effect of adrenergic signaling in both liver and muscle cells is glycogenolysis Forskolin a drug that increases intracellular concentration of cAMP will lead to increase/decreasein blood glucose levels G protein coupled receptors (GPCR) are a popular way of signaling all over the body List 2 more processes that use GPC'R receptor signaling PCR use second messengers to pass the signal inside the cell List 3 most common second messengers What types of targeting sequences are present in sequence of GPC'Rslike adrenaline receptors? Think about final destination og GPCR in the cell multiple start and stop" sequences

Explanation / Answer

49. Mitochondria, Endoplasmic reticulum

52.Forskolin activates adenylate cyclase, which increases intracellular cAMP levels. The antioxidant and antiinflammatory action of forskolin is due to inhibition of macrrophage activation with a subsrquent reduction in thromoxane B2 and superoxide levels.These characteristics have made forskolin an effective medication for heart disease, hypertension, diabetes, and asthma.Evaluated the effectes of chronic forskolin administration on blood glucose and oxidative stress in 19 rates. Rates are treated with forskplin for 8 weeks .Glucose was measuring fasting blood glucose in rats.faskolin treatment lowered the fasting glucose at end of the experiments So the result is forskolin is decresed fasting blood glucose level.

53.Internal receptors

54. Cell-surface receptors

55.Cyclin nucleotides(e.g. cAMP and cGMP)

56.Inositol trisphosphate(IP3)and diacylglycerol(DAG)

57.Calcium ions

58.G protein- coupled receptors(GPCRs) which are also called as seven transmembrane domain receptors, 7TM receptors, Heptahelical receptors,Serpentine receptors, and S protein -linked receptors(GPLR)

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