Upon analyzing a sample of cells from a patient, you find the lysosomes to be fi

Question

Upon analyzing a sample of cells from a patient, you find the lysosomes to be filled with undigested material. This observation makes you think that the lysosomes are not functioning properly. Which of the following could account for the defective lysosomes (choose all that apply)?

A) defect in transport of small molecules from digested materials into the cytosol

B) defect in the mannose-6-phosphate receptor in the Golgi apparatus

C) defect in the lysosomal proton pump

D) defect in a digestive enzymes

E) defect in the process of adding a mannose-6-phosphate signal to lysosomal enzymes

F) defect in receptor-mediated endocytosis

Explanation / Answer

Ans).

E) defect in the process of adding a mannose-6-phosphate signal to lysosomal enzymes

F) defect in receptor-mediated endocytosis

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