predict the outcome of a mutation where the codon CUC is changed to AUC. Be sure
ID: 175935 • Letter: P
Question
predict the outcome of a mutation where the codon CUC is changed to AUC. Be sure to include what amino acids are being exchanged. (HINT: compare and contrast the structures)predict the outcome of a mutation where the codon CUC is changed to AUC. Be sure to include what amino acids are being exchanged. (HINT: compare and contrast the structures)
predict the outcome of a mutation where the codon CUC is changed to AUC. Be sure to include what amino acids are being exchanged. (HINT: compare and contrast the structures)
Explanation / Answer
ANS:
It is a point mutation. The change of a single nucleotide in a DNA’s template strand leads to produce an abnormal protein.
A point mutation is a failure of by the replicating the cell to copy the genetic information accurately. Point mutation may be beneficial, harmful or neutral (having no effect on the organism)
A point mutation is classified into 3 major types. They are…
1. Substitution point mutation: Change of a nucleotide or few nucleotides from one type to another.
2. Insertion point mutation: An insertion of one or few nucleotides in the DNA sequence.
3. Deletion point mutation: A deletion of one or few nucleotides in the DNA sequence.
In the point mutation one base is substituted for another, 3 possible consequences are possible..
A. Non- sense mutation: Codes for a stop, which can translate the protein.
B. Miss-sense mutation: Codes for different amino acid.
C. Silent mutation: Code for the same amino acid.
According to the given question it is a Miss-sense mutation.
Miss-sense mutation:
Miss-sense mutation that results in an altered codon that codes for a different amino acid.
In Miss-sense mutation one gene affect only the conserved enzyme. Therefore there mutons were used to assign the three enzymes to the three structural genes.
A missense mutation in
1. Lac opern -Z affects -Galactose
2. Lac opern -Y affects Permease
3. Lac opern -A affects Trans acetylone.
Normal m-RNA Sequence:
Effect introducing in m-RNA Sequence:
MRNA SEQUANCE: AUG UUG UCA AAA CUC UGG CGG CCA
AMINO ACIDS: met leu ser lys Leu trp arg pro
After a single nucleated replaced (A instead of C in CUC)
MRNA SEQUANCE: AUG UUG UCA AAA AUC UGG CGG CCA
AMINO ACIDS: met leu ser lys ILE trp arg pro
Effect: Incorrect amino acid which may produce a MALFUNCTIONING protein.
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