The table below shows the effects of various treatments on the in vitro prolifer

Question

The table below shows the effects of various treatments on the in vitro proliferation of cartilage, fibroblast and hepatoma cells. The different treatments in the experiment were as follows: none (i.e., control), epidermal growth factor (EGF), liver-cell growth factor (LCGF), recombinant retrovirus carrying the oncogene v-erbB (retrovirus), and antibody raised against the EGF receptor (receptor antibody). (Increasing number of +'s indicate increasing cell proliferation/growth) Which of the following statements about this cell treatment experiment is LEAST likely? One or more cell types have receptors for more than one growth factors. Hepatoma cells have an LCGF receptor but not an EGF receptor. Growth factors show some specificity regarding target cell types. EGF and LCGF trigger growth by binding with different affinities to the same receptor

Explanation / Answer

b) Hepatoma cells have an LCGF receptor but not an EGF receptor

Many growth factors, such as epidermal growth factor (EGF), are associated with the carcinogenesis. EGF plays its role in the proliferation of hepatoma cells through binding with EGF receptor (EGFR) and a series of signal transduction.

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