Question V. Serologic testing before liver transplantation reveals that the leuk

Question

Question V. Serologic testing before liver transplantation reveals that the leukocytes of a prospective recipient are killed by anti-HLA-A3, anti-HLA-B7, and anti-HLA-Cw7 antibodies in the presence of complement. You can conclude that [assess the following statements (97-104) describing various hypothetical conclusions as either factually correct (true) or incorrect (false)

97. The potential liver donor and the prospective recipient are siblings.
98. The potential liver donor and the prospective recipient are not siblings.
99. The potential liver donor and the prospective recipient are identical twins.
100. The potential liver donor and the prospective recipient are not identical twins.
101. The prospective liver recipient should not receive a liver graft that expresses the HLA-A3, HLA-B7 and HLA-Cw7 antigens.
102. If the prospective liver recipient receives a liver graft that expresses the HLA-A3, HLA-B7 and HLA-Cw7 antigens, sooner or later, the graft will be rejected.
103. The prospective liver recipient expresses the HLA-A3, HLA-B7 and HLA-Cw7 antigens. 104. The prospective liver recipient does not express the HLA-A3, HLA-B7 and HLA-Cw7 antigens.

Explanation / Answer

Statement 103 is True.The situation describes that leucocytes of the prospective recipient are killed by anti-HLA-A3, anti-HLA-B7, and anti-HLA-Cw7 antibodies in the presence of complement.It clearly indicates that the cells express these determinants.

For Statements 97,98,99,100-- Insufficient information / Incorrect.No information regarding HLA phenotypes of siblings or twins is provided.

For Statement 101."The prospective liver recipient should not receive a liver graft that expresses the HLA-A3, HLA-B7 and HLA-Cw7 antigens." Incorrect. It is desirable to graft the prospective recipient with a liver graft that expresses these determinants.

Statements 102 and 104 are Incorrect.

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