The growth factor Superchick stimulates the proliferation of cultured chicken ce

Question

The growth factor Superchick stimulates the proliferation of cultured chicken cells. The receptor that binds Superchick is a receptor tyrosine kinase (RTK), and many chicken tumor cell lines have mutations in the gene that encodes this receptor. For the following types of mutation, what would be the affect if any on cell proliferation? (a) a mutation that prevents dimerization of the receptor (b) a mutation that destroys the kinase activity of the receptor (c) a mutation that inactivates the protein tyrosine phosphatase that normally removes the phosphates from tyrosines on the activated receptor (d) a mutation that prevents the binding of the normal extracellular signal to the receptor

Explanation / Answer

Answer : C a mutation that inactivates the protein tyrosine phosphatase that normally removes the phosphates from tyrosines on the activated receptor. (They are called “receptor like” because the presumptive ligands have not yet been identified, and so their receptor function has not been directly demonstrated)

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