HPV-16 is the primary causative agent of cervical cancer and is increasingly imp

Question

HPV-16 is the primary causative agent of cervical cancer and is increasingly implicated in many mouth & throat cancers. How do 3 HPV-encoded proteins work synergistically to promote cell proliferation?

A. E5 mimics PDGF; E6 ubiquitinates Rb causing its degradation; E7 binds p53 and prevents its binding to the p21CIP gene. B. E5 mimics PDGF; E6 ubiquitinates p53 causing its degradation; E7 binds cyclin D/CDK and activates it. C. E5 mimics PDGF; E6 ubiquitinates p53 causing its degradation; E7 binds Rb and prevents its binding to E2F. D. E5 truncates the EGF receptor converting it to the ErbB oncoprotein; E6 ubiquitinates p53 causing its degradation; E7 binds Rb and prevents its binding to E2F. E. E5 truncates the EGF receptor converting it to the ErbB oncoprotein; E6 phosphorylates p53 inactivating it; E7 binds E2F and inhibits its activity.

Explanation / Answer

Ans). D. E5 truncates the EGF receptor converting it to the ErbB oncoprotein; E6 ubiquitinates p53 causing its degradation; E7 binds Rb and prevents its binding to E2F.

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