Article Review 3 You are to write a summary of the following article: (Note, thi

Question

Article Review 3

You are to write a summary of the following article:

(Note, this is an open access journal)

Bouwman, B. A., & de Laat, W. (2015). Getting the genome in shape: the formation of loops, domains and compartments. Genome Biology, 16 (1), 1–9. https://doi.org/10.1186/s13059-015-0730-1

http://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0730-1

In this article, I want you to focus on the following items:

1.      What is the background (what are the authors trying to do with this research). For example:

1.      What are they interested in?

2.      NOTE: This is a review article, which means the authors are compiling and discussing previous research in this field. Consider why an author would want to do this. This will help you to explain the author's interest in the field, and the background.

2.      Specific Details that must be in your summary (You are writing an essay, so don't just answer the questions. Each point is worthy of at least one paragraph):

1.      Describe the thesis/hypothesis.

§ NOTE: This is a review article, so what you are trying to do is figure out the main theme. This will help you to word a thesis statement.

2.      What is meant by Hierarchical Genome Structure?

3.      What are chromosomal regions?

4.      What are Topologically Associating Domains (TADs), and why are they important? (what is the function)

5.      What is a genomic neighborhood? (Use Figure 1 to help you explain the concept)

6.      What is meant by chromosomal loops? (Use Figures 2 and 3 to help you explain the concept).

7.      What conclusions do the authors reach?

8.      Provide a reflection of what you learned from reading this paper.

Remember, you must write this in essay format, and your writing must be of collegiate standard (review, revise, & edit). Remember, you are not trying to rewrite the article, but provide a brief summary that demonstrates your understanding of the article.

Explanation / Answer

1: The article is about topology of genome i.e. structural details of loops, domains and compartments and their effect on the gene regulation. Since these topological factors regulation the gene expression as the level of transcription by regulating the accessibility of genes and regulatory elements.
2: The authors have collected the relavent data about genome topology in human and have described the strcutral features of these genomic heirarchial levels with respect to their effect on regulation of gene expression. The author is interested in studying the effects of genome topology on the genome functioning.

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