A certain mutagen causes a specific base change, resulting in non-complementary

Question

A certain mutagen causes a specific base change, resulting in non-complementary base pairing and a point mutation. The mutagen does not affect every instance where this base occurs, but it causes the same base change in each case. In each case below, the mutation occurred on the nontemplate strand of DNA. What base change is caused by this mutagen? The coding dictionary is provided on the last page of this homework. G changed to A G changed to T T changed to C A changed to G Case 1. Wild Type: ... trp-thr-pro-arg-ala ... Mutant: ... trp-thr-pro-his-ala ... Case 2. Wild Type: ... Icu-asp-arg-ala-ser ... Mutant: ... leu-asn-arg-ala-ser ... Case 3. Wild Type: ... ser-thr-gly-trp-thr ... Mutant: ... ser-thr-gly

Explanation / Answer

7.

Case 1.

wild type - trp - thr - pro - arg - ala

Mutant - trp - thr - pro - his - ala

Here the answer is: a. G changed to A

CGT to CAT / CGC to CAC /

Case 2

wild type - leu - asp - arg - ala - ser

Mutant - leu - asn - arg - ala -ser

The answer is: d. A changed to G

AAT to GAT / AAC to GAC

Casr 3.

wild type - ser - thr - gly - trp - thr

Mutant - ser - thr - gly

The answer is: a. G changed to A

Trp is replaced by a stop codon

UGG to UAG or UGG to UGA or UGG to UAA

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