HI experts can you help me with my Endocrinology physiology case study? A 50-yea

Question

HI experts can you help me with my Endocrinology physiology case study?

A 50-year old Caucasian female patient presented for a follow-up from surgery on her middle ear. Because of on-going complaints of fluttering, and hearing loss in her left ear an MRI of the internal auditory canals was performed and incidentally suggested a pituitary mass. Upon evaluation by an endocrinologist, the patient noted a recent truncal weight gain and commented that she bruised easily. Past medical history was notable only for mild controlled hypertension. A laboratory evaluation revealed the following. ACTH: 118 pg/mL (9-46) TSH: 3.35 mU/L(0.3-5.0) Prolactin: 9.9 ng/mL (3-30) Growth Hormone: 0.51 ng/mL (

Explanation / Answer

1). The higher levels of cortisol can be released under the following conditions:

a). Tumours of the adrenal gland

b). Excessive release of ACTH (adrenocorticotropic hormone) from the anterior pituitary, this can occur in case of pituitary tumors.

c). Excessive release of ACTH-releasing hormone from the hypothalamus

d). Noncancerous tumor of the pituitary gland (benign tumour)

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