Biochemistry help please! Pyruvate dehydrogenase is the entry point for the glyc
ID: 173962 • Letter: B
Question
Biochemistry help please!
Pyruvate dehydrogenase is the entry point for the glycolytic product pyruvate into oxidative metabolism (the citric acid cycle and oxidative phosphorylation). Because it occupies such an important checkpoint in metabolism, it is tightly regulated. (a) Determine whether the following conditions promote entry into oxidative metabolism or limit entry into oxidative metabolism. The following abbreviations may be used: PDH is pyruvate dehydrogenase; PDK is pyruvate dehydrogenase kinase; PDP is pyruvate dehydrogenase phosphatase.
Determine whether the following conditiions promote entry into oxidative metabolism or limit entry into oxidative metabolism. The following abbreviations may be used: PDH is Pyruvate Dehydrogenase; PDK is Pyruvate Dehydrogenase Kinase; and PDP is Pyruvate Dehydrogenase Phosphatase.
Oxidative Metabolism Increases Oxidative Metabolism is Limited
Choices to place in the above two catagories:
high O2 levels, active PDP
high O2 levels, PDK inhibitor present
high O2 levels, inactive PDH
high O2 levels, PDK active
low O2 levels, PDK active
Explanation / Answer
Oxidative Metabolism Increases :-High O2 levels, active PDP, High O2 levels, PDK inhibitor present.
Oxidative Metabolism is Limited:- low O2 levels, inactive PDH,
high O2 levels, PDK active
Low O2 levels, PDK active
Oxidative metabolism is a chemical process in which oxygen is used to make energy or adenosine triphosphate (ATP) from carbohydrates. Metabolism of simple sugar (glucose) produces two pyruvate molecules that enter in the mitochondria of the cell and Krebs cycle is initiated here.
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