1) In some autoimmune disorders, chemokines bind GPCRs to direct immune cells to
ID: 173913 • Letter: 1
Question
1) In some autoimmune disorders, chemokines bind GPCRs to direct immune cells to sites that are not actually foreign invaders. Which of the following might be a treatment for such disorders?
A non-hydrolyzable GTP analog
A dominant-negative receptor
A molecule that constitutively blocks the ligand-binding site.
An inhibitor of arrestin.
2) When bacteria are consumed by macrophages, the macrophages give off chemokines to recruit other immune cells. The chemokines serve as ligands for G-protein coupled receptors. Which of the following is NOT true of G-PCRs?
GPCRs require GTP for pathway activation.
GPCRs bind the ligand extra-cellularly and undergo an allosteric change.
The receptor is a G-protein
The G-protein is lipid anchored.
A non-hydrolyzable GTP analog
A dominant-negative receptor
A molecule that constitutively blocks the ligand-binding site.
An inhibitor of arrestin.
Explanation / Answer
1.A non-hydrolyzable GTP analog is used for the treatment for autoimmune disorders.
2.D the G protein is lipid anchored.
G proteins that associate with GPCRs are heterotrimeric,they have three different subunits: an alpha subunit,a beta subunit,and a gamma subunit.Two of these subunits are alpha and gamma which are attached to the plasma membrane by lipid anchors.G protein alpha subunit binds either GTP or GDP depending on whether the protein is active (GTP) or inactive (GDP).
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