1) In children that express recessive genetic diseases , it has been occasionall

Question

1) In children that express recessive genetic diseases, it has been occasionally found that only one parent is heterozygous for the disease allele. In these cases, it has also been confirmed that the parents are the true biological parents of the affected child. Which explanation best accounts for this if the father is the carrier? May have more than one answer, select all possibilities.

a) Mother’s normal egg is fertilized by a sperm that went through nondisjunction in Meiosis I

b) Mother’s egg went through nondisjunction in meiosis II and is fertilized by sperm that went through nondisjunction in meiosis II

c) Mother’s egg that went through nondisjunction in Meiosis II and is fertilized by father’s normal sperm

d) Mother’s egg went through nondisjunction in meiosis I and is fertilized by sperm that went through nondisjunction in meiosis I

e) Mother’s egg went through nondisjunction in meiosis I and is fertilized by sperm that went through nondisjunction in meiosis II

f) Mother’s egg that went through nondisjunction in Meiosis I and is fertilized by father’s normal sperm

g) Mother’s normal egg is fertilized by a sperm that went through nondisjunction in Meiosis II

h) Mother’s egg went through nondisjunction in meiosis II and is fertilized by sperm that went through nondisjunction in meiosis I

Use the same information for the following two questions:

2) A female patient has had a lifelong battle with sever muscle weakness. When her doctor examines her genome, he saw the following. What type of chromosomal mutation does she have?

choose one of the answers below:

a) inversion

b) Nonreciprocal translocation

c) Reciprocal translocation

d) duplication

e) Robertsonian translocation

f) Deletion

3) After the doctor discusses his findings with his patient, she wants to know what the probability is of passing this on to her offspring. Determine what gametes she can produce, and whether those gametes would be viable or not when fertilized with the sperm of a male with normal chromosomes 14 and 21. Use the image in the previous problem, where A, B, and C represent each chromosome. Each answer choice below represents a possible gamete combination. (Select all that apply).

a) B,C = muscle weakness

b) A,C = normal

c) C = muscle weakness

d) A,B = normal

e) A,C = not viable

f) A = normal

g) C = not viable

h) B = not viable

i) A,B = muscle weakness

j) B = normal

k) A = muscle weakness

l) B,C = not viable

m) B,C = normal

n) C = normal

o) B = muscle weakness

p) A,B = not viable

q) A,C = muscle weakness

r) A = not viable

Explanation / Answer

1) b) Mother’s egg went through nondisjunction in meiosis II and is fertilized by sperm that went through nondisjunction in meiosis II

2) b) Nonreciprocal translocation

3) h) l) p) These combinations will be not viable.

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