A 17-year-old black male is admitted to the hospital in sickle-cell crisis. You

Question

A 17-year-old black male is admitted to the hospital in sickle-cell crisis. You then find out that he has sickle cell disease. a. How is this different from sickle cell trait? b. Would either or both of his parents have sickle trait or disease? Explain which, if either, they must have and how you know. c. Additional questioning reveals that he was playing sports when he entered this crisis. Why might you expect this? d. Pain management is a top priority for patients in sickle-cell crisis. Explain why and where they would experience pain

Explanation / Answer

1. People with sickle cell trait (AS) inherit one gene for normal hemoglobin (A) and one gene for sickle hemoglobin (S) from their parents. Because they have one (A) gene, individuals with trait do not have any medical problems, but they can pass the (S) gene to their children. People with sickle cell disease (SS) inherit two genes for sickle hemoglobin (S) from their parents. They have symptoms because their red blood cells do not make normal hemoglobin.

2. Sickle cell disease is an inherited condition. Two genes for the sickle hemoglobin must be inherited from one's parents in order to have the disease. A person who receives a gene for sickle cell disease from one parent and a normal gene from the other has a condition called "sickle cell trait. Both the parents need to transmit the gene for sicke cell disease.

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