It\'s Friday at 10:00 p.m in the transfusion service, and you are the only techn

Question

It's Friday at 10:00 p.m in the transfusion service, and you are the only technologist that section. A sample from a 25-year-old Black female who is bleeding from an auto accident is sent to the lab for a STAT crossmatch for 6 units of red blood cells. The patient types as O Rh-negative; and the screen is positive at the AHG phase. What you do? Patient records for the patient in question 6 indicate one previous pregnancy and no transfusions. The panel results show an antibody reaction at AHG with ALL cells and similar strength, but the autocontrol is negative. What do you suspect?

Explanation / Answer

Although the woman was Rh-negative his womb carried a Rh positive foetaus and somehow her blood got D antigen from the foetal blood. Rh-positive recipients can receive Rh positive or Rh negative RBCs, but Rh-negative recipients should only receive Rh-negative blood. Here antibody screening test was done to detect unexpected antibody. This is done through AHG test (auto human globulin reagent). She is autocontrol negative means she has alloantibody.

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