It was shown that some of the infecting bacteria is capable of invading the smal
ID: 262963 • Letter: I
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It was shown that some of the infecting bacteria is capable of invading the small channels of bone (canaliculi) in order to evade the immune system and continue to grow. An in vitro model was designed to mimic the propagation of bacteria through sub-micron pores to study this image of bacterial cells on the membrane. Topside de Mesy Bentley, K. L, et al. JBMR 2017 Assume that bacteria have similar cell surface receptors as mammalian cells and can use them to interact with the membrane material. Bacteria Surface ReceptorX is important for invasion of a) How would you change the properties of the membrane to activate Surface Receptor X? Explain with drawings showing before and after membrane modifi b) Should the modification selected in part (a) be temporary or permanent and why? Additionally, what method would you use to modify the membrane surface?Explanation / Answer
Osteomyelitis caused by bacteria like Staphylococcus Aureus is considered to be incurable. Studeissyggest that this bacteria enters into bone tissue and kills the osteocytes and osteoblast through the mechansim of necrosis and programmed cell death. They are also found to be invasive in osteocyte lacunae and canaliculi as chain of cocci or forms an biofilm.
The topography of the bacterial cell surface decides its nature of invasion in vitro or in vivo.:-
a) By using aptamers as artificial receptor to connect with host cell surface protein. This process is reversible and contrable and rapid as well. These aptamers are lipid molecule.Any aptamers can be functionalised with other molecule as it protrude out of the cell and react with any miolecule in cell of its specificity.
B) As it reversible and could be temporary and permanent depend on the need.
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