Sally works in a pharmaceutical company and has discovered a chemical that block

Question

Sally works in a pharmaceutical company and has discovered a chemical that blocks the ability of Ran to exchange GDP for GTP. What is the most likely effect of this chemical on nuclear transport of proteins? Which of the following statements is true? Please correct any statements that are false. (a) The signal sequences on mitochondrial proteins are usually at the C-terminus. (b) Most mitochondrial proteins are not imported from the cytosol but are synthesized inside the mitochondria. (c) Chaperone proteins in the mitochondria facilitate the movement of proteins across the outer and inner mitochondrial membranes. (d) Mitochondrial proteins cross the membrane in their native, folded state.

Explanation / Answer

Answer 4 (a) False- most of the signal sequences on mitochonrdial proteins are at the N-terminus.

(b) False- proteins are mostly imported from the cytosol which is a quick process. Mitochondrial proteins are first fully synthesized as pre-cursor protiens in the cytosol and then translocated into the mitochondria by a posttranslational mechanism.

(c) True

(d) False- mitochondrial proteins cross the membrane unfolded through interactions with different proteins such as chaperone proteins.

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