While many of the genes identified through genetic studies of Microcephaly appea
ID: 167067 • Letter: W
Question
While many of the genes identified through genetic studies of Microcephaly appear to operate via disruption of normal cell division by disrupting centromere function, one gene - MCPH1, may block cell division through inhibitory phosphorylation of cyclin-dependent kinase 1. Protein products from the Zika virus polyprotein could mimic this function. Search for MCPH1 in NCBI Gene. Select the NC_00008.11 record. Select from the RefSeq Protein microcephalin isoform 1 (NP_078872.2). BLAST this protein against Zika virus (taxid:64320) setting word size 2, and using PAM250 (with its adjustment of Gap Costs to Existence:14 and Extension:2). Select all that apply: The BLAST query recovers the Zika Virus nonstructural protein 5. The E-value for the protein recovered indicates its alignment is unlikely to be due to chance alone. The Identity of the recovered protein is less than 30%. The records recovered by examining accession number for the protein indicates that it is an RNA-directed RNA polymerase.Explanation / Answer
The results obtained as a result of BLAST
The BLAST query recovers the Zika Virus non structural protein 5.
The E value for the protein recovered indicates its alignment is unlikely to be due to chance alone.
The identity of the recovered protein is less than 30 %.
The records recovered by examining accession number for the protein indicates that it is an RNA directed RNA polymerase.
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