Dr. Mathers thinks that copper deficiency may cause a loss in bone density. He k

Question

Dr. Mathers thinks that copper deficiency may cause a loss in bone density. He knows that copper deficiency causes a loss of pigmentation in hair in bicolored black & white rats after four weeks (images may or may not show up - it does not affect your ability to answer the question.) Previously you helped design his experiment. Now you need to collect data including weight, coat color (white or bicolored), and bone density results. Bone Mineral Density (BMD) results are collected in g/cm2. A scale is used to record after the experiment, which is either white or bicolored. This is a form of (blank) data which is a type of (blank) data. At the end of the experiment, some rats have no black pigment. What causes a bicolored rat to become all white? (blank) Before and after the experiment, a (blank) scale is used to record which is measured in grams. This is a form of (blank) data which is a type of (blank) data. Before and after the experiment, is measured in g/cm g/cm2 using a scale.This is a form of data which is a type of data. A scale is used to record after the experiment, which is either white or bicolored. This is a form of (blank) data which is a type of (blank) data. At the end of the experiment, some rats have no black pigment. What causes a bicolored rat to become all white?(black) Before and after the experiment, a (blank) scale is used to record which is measured in grams. This is a form of (blank) data which is a type of (blank) data. Before and after the experiment, is measured in g/cm g/cm2 using a (blank) scale.This is a form of (blank) data which is a type of (blank) data.

Explanation / Answer

The effects of a low copper diet on pigmentation, pigment cell and melanosome morphology have been investigated in ACI/T male rats. After a three months treatment the fur and skin pigmentation is reduced as compared to the controls. The melanocytes of the treated rats show the phenotype of active pigment cels while some melanosomes are abnormal melanosome structures expressed by the treated-rat melanocytes is also evident in vitro. after incubation with deoxyholate the melanosomes from the low copper diet treated rats are much more altered than those from the control rats. The phenotype of the rats starved for copper seems to mimic as regards pigmentation the phenotype of the mouse MO (mottled) mutation that is an experimental model of the Menkes' kinky hair syndrome. In conclusion copper deficiency seems to affect both the morphology and function of the pigment cells. That causes bicoloured rat to became all white.

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