Vascular Ehlers-Danlos Syndrome (vEDS) is characterized by fragile and thin arte
ID: 164863 • Letter: V
Question
Vascular Ehlers-Danlos Syndrome (vEDS) is characterized by fragile and thin arteries and therefore leads to ruptures of arteries as well as other arterial events. How would angiotensin II receptor blockers help reduce the occurence of these vascular complications from happening? I know that the renin-angiotensin system has a pivitol role in the progression of arterial stiffness. But if we block Ang II, it would alleviate the stiffness of the arteries, thus making them more thin and fragile which I would think is not favored if you have vEDS. Please help!
Explanation / Answer
The treatment and management of vascular ehler danlos syndrome is focussed on relieving associated signs and symptoms and preventing serious complications. It is caused due to defect in type III collagen. Renin angiotensin reduces the aortic dilation and also reduces the risk of aortic dissection. This is done by increasing the stiffness of artery walls so that they can resist their dilation and prevent their breakage. Ongoing studies prove the effectiveness of angiotensin blockers over beta blockers.
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