Question: What type of gene or gene function appears to be the most complexly re

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Question: What type of gene or gene function appears to be the most complexly regulated in the human genome, based on abundance of "distal DHS" to promoter interactions? and binding site methylation specifically within acute promydocytic leukaemia cells (NB), andboth interact with promyelokyticleukaemia (PML bodies" a sub nudear structure disrupted in PML cells. The anomalous behaviour ofthese two transcription factors with respect to chromatin structure and DNA methylation may thus be related to a specialized mechanism seen only in pathologically altered cells. A map of distal DHS-to-promoter connections From examination of DNasel profiles across many cell types observed that many known cell-selective enhancers become DHSs nchronously with the appearance of hypersensitivity at the pro- moter of their targetgene (supplementary Fig 13. To generalize this, we analysed the patterning of1A54,901 distal DHSS (DHSs separated from a Tss by at least one other DHS across 79 diverse cell types Distal DHSs conneenad Promoter DHSe connected (Supplementary Methods and Sapplementary Table 6), and corre- per promoter DHS per distal DHS lated the cross-cell type DNase signal at each DHS position with that at all promoters within 500 kb (Supplementary Rig, 14a). We 1-10 identified total of578905DHSethat were highly correlated (r 07 with at least one promoter (P

Explanation / Answer

DHS is DNase I hypersensitivity sites which are regions on chromatin that are sensitive to DNase I enzyme. These DHS are mostly used as markers of regulatory DNA enzymes which occupy 95 % in the human genome and lets us to understand the complexity in regulating the genetic expression of the human genome.

So here, the promoters that related to more than one enhancer sequences are considered more complexly regulated. As the essay suggest, the number of distal DHS connected to a specific promoter is a quantitative measure of the complexity in regulation. The KLF4 promoter is complexly regulated as per the essay.

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