The pedigree below shows three generations of a family affected by a genetic dis

Question

The pedigree below shows three generations of a family affected by a genetic disorder Z. Disorder Z is caused by mutations in a single gene, and it shows multiple symptoms such as muscle paralysis, nerve disorders, abdominal pain, and photosensitivity. Three of the symptoms are represented in the pedigree below Select the mode of inheritance of disorder Z. Y-linked dominant autosomal recessive X-linked recessive X-linked dominant autosomal dominant Select the genetic phenomena displayed by the pedigree of disorder Z. genetic anticipation pleiotropy incomplete penetrance expressivity

Explanation / Answer

The mode of inheritance of the disorder Z is Autosomal dominant.

Parents (1 & 2) are both affected but have produced unaffected offspring (5). Therefore 1 &2 must have been carrying recessive healty alleles. If it were recessive, it would need to be homozygous to be expressed in 1 & 2- and then all the offspring would be homozygous recessive. So it is Dominant.

Male 4 can pass only one X chromosome. If it is carried on X , daughter 11 would be affected by the dominant allele. So it is not sex linked. It is Autosomal.

The genetic phenomena displayed by the pedigree of disorder Z is Pleotropy, because of mutation in a single gene produced multiple phenotypic effects.

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