In the follow-up work to the experiment shown in the figure below, the researche

Question

In the follow-up work to the experiment shown in the figure below, the researchers used a technique that allowed them to see if two DNA sequences are in close physical proximity (association). They applied this method to examine how often an enhancer and the core promoter of the Hnf4a regulatory gene were near each other.

A logical prediction is that compared with rats born to mothers fed a healthy diet, the Hnf4a gene in rats born to mothers fed a protein poor diet would

RESEARCH QUESTION: Does poor nutrition in a mother produce epigenetic effects in offspring? EXPERIMENTAL SETUP: 1. Provide rat mothers with a normal or a low-protein diet during pregnancy and while nursing. 2. After weaning, feed rat pups a normal diet and raise to old age. 3. Determine types of histone modifications for a regulatory gene involved in diabetes and measure transcription Modifications Modifications promoting promoting RIPTION Hnf4a condensed decondensed chromatin chromatin RESULTS: Modifications promoting 2.0 2 2.0 condensed Modifications chromatin promoting 1.8 1.8 decondensed 1.6 chromatin O 1.6 Hnf4a g 1.4- transcription 1.4 2 1.2 1.2 0.8 0.8 0.6 E 0.6 0.4 0.4 0.22. 0.2 Normal Low Normal Low Normal Low diet protein diet protein diet protein CONCLUSION: A mother's diet influences chromatin modifications and gene expression patterns throughout her offspring's life.

Explanation / Answer

The answer is: show a lower frequency of promoter-enhancer association.

Since Hnf4a codes for transcription factor so poor diet will lead to low levels of transcription factor which will lead to a lower frequency of promoter-enhancer association.

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