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1) Imagine that a pharmaceutical company, specifically the research and developm

ID: 15472 • Letter: 1

Question

1)    Imagine that a pharmaceutical company, specifically the research and development division, just hired you. Your first assignment consists of developing a new anticancer drug to control the high rates of glycolysis in tumor cells. Your company wants to target an enzyme different to hexokinase II, because they want to get ahead of competition (hexokinase inhibitors are popular drugs). What glycolytic enzyme (s) would target? Why? If you are not successful targeting glycolytic enzymes, how would you attempt to inhibit glycolysis? Provide at least one example to support your answer.  

Explanation / Answer

Answer: Aim for phosphofructokinase or pyruvate kinase. Why? Because these steps are unidirectional and are often regulated within the cell. The phosphofructokinase step is also known as the 'committed step'. Any compound that reaches and finishes that step will go on to complete glycolysis because there are no other diverging pathways for the compound to go. Not successful? Try creating a drug that automatically converts any of the intermediates to another useless compound. For example, convert any GAP to DHAP. This will screw over the equilibrium between these two compounds. Since glycolysis needs GAP to continue through the second payoff stage, it will be stuck for the most part.

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