BIOL2416-41480: Genetics ourse Home Chapter 19: Epigenetics Chapter 19-Question

Question

BIOL2416-41480: Genetics ourse Home Chapter 19: Epigenetics Chapter 19-Question 18 PartA Which of the following statements is the most accurate in regards to mice pups who receive less maternal nurturing? O As adults their brains are heavily mutated. O As adults they have increased ability to adapt to stress. O As adults they are more likely to nurture their offspring. O As adults they have increased promoter methylation. O As adults they have high levels of glucocorticoid receptor expression. Submit

Explanation / Answer

Maternal nurturing in mice involves licking the pups by mother. This is an early way of epigenetic regulation in mice. It has been incessantly studied and experiments have proved that epigenetic regulation of gene transcription takes place when the mother licks a pup in mice. Licking causes demethylation of portions of DNA which contain the gene for the transcription of Glucocorticoid receptors. Mice with higher levels of Glucocorticoid receptors detect cortisol better, and they recover from stress easily. Since the question is about mice pups who do not receive nurturing, the Answer is "As adults, they have increased promoter methylation"

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