Liver-damage is a dangerous side-effect of many drugs and serves as a limitation

Question

Liver-damage is a dangerous side-effect of many drugs and serves as a limitation on the development of new therapeutics. One drug notorious for liver damage is the common pain reliever acetaminophen. Studies have shown that mice that are mutant for the connexin 32 gene are protected from drug-induced liver injury, and chemicals that inhibit gap junctions can also block hepatotoxicity. What does this suggest about the mechanism of drug-induced liver injury? Q33: A) The damaging substance must enter the cell's exposed apical membrane via endocytosis B) Working gap junctions are necessary to allow the passage of white blood cells, so the liver can C) The liver cells become damaged and nonfunctional when gap junctions are blocked by D) Substances cause liver damage when passed from cell to cell via gap junctions. E) Substances cause liver damage when passed from cell to cell by passive diffusion across cell heal after drug-induced damage. acetaminophen. membranes

Explanation / Answer

The mechanism of drug induced liver injury is as follows:

D) Substances caused liver damage when passed from cell to cell via gap junctions.

Connexin 32 is a hepatic gap junction protein which pass the toxic substance from cell to cell but its mutation does not allow toxic substances from cell to cell and prevents drug induced liver injury.

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