1. The most common mutation found in sickle cell anemia is an amino acid substit
ID: 149664 • Letter: 1
Question
1. The most common mutation found in sickle cell anemia is an amino acid substitution in which a glutamic acid residue is replaced by a valine in the gene for Hemoglobin, dramatically disrupting the protein structure and function. Which amino acid subsitution for glutamic acid would you expect to have less of an impact on protein structure? a. lysine b. alanine c. aspartic acid Among the following choices, where are hydrophobic interactions most likely to occur? a. b. c. d. e. d. tryptophan 2. between two ions between two charged molecules between amino acids of a peripheral membrane protein and the cytosol on the surface of a water-soluble protein at the core of a water-soluble protein between amino acids CH NH, CH CH -- H o Threonine (Thr or T) Cysteine (Cys or C) Glutamic acid (Glu or E) Lysine (Lys or K) Valine (Val or V 3. Which of the amino acids pictured above can be covalently modified by addition of a phosphate group by a kinase? a. b, B C. d. D e. The first culture of human cells was begun by George and Martha Gey at Johns Hopkins University in Baltimore city, which is the topic of a recent popular book. The cells were obtained from a malignant cervical tumor and named a. culture cells, Henrietta Lacks 4. after the patient from which they were obtained, d. culture cells, an anonymous person b. 293 cells, Henrietta Lacks HeLa cells, Henrietta Lacks e. HeLa, Herbert Lane c. cs was discovered by electron microscopy and distinguishes prokaryotic and eukaryotic cell types? a. b. c. number of chromosomes color presence or absence of organelles presence or absence of a cell wall cell shape d. e.Explanation / Answer
1 - The correct answer is option E that is aspartic acid.
Both glutamic acid and aspartic acid are acidic amino acid. So substituting glutamic acid by aspartic acid will have less effect on protein structure.
2 - The correct answer is option E that at the core of a water soluble protein between amino acids.
Hydrophobic amino acids are water repulsive and can not be in contact with any water molecule that is why it has to be away from water contact and that is why they are at the core of water soluble proteins.
3 - The correct answer is option A that is threonine.
To add phosphate group on amin acids OH group is necessary. So, either serine or threonine can be used to add phosphate group by a kinase.
4 - The correct answer is option C that is HeLa cells,, Henrietta Lacks.
5 - The correct answer is option C that is presence or absence of organelles.
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