Reconstructing a protein sequence by similarity to another species So, polypepti

Question

Reconstructing a protein sequence by similarity to another species So, polypeptide sequences can be determined by combining information from two sets of peptide fragments. It's also possible to determine the correct order for a set of peptide fragments by comparison with the sequence of the same protein from another species. For example, suppose we had only the set of Glu-C peptides from a human protein: 1) AspLeuIleAlaTyrLeuGlu 2) MetIlePheAlaGlyIleLysGlyGlu 3) ArgGlu But we know the sequence of the same protein from another species, say cow: MetValPheSerGlyIleArgGlyGluArgAspAspvalIleAlaTyrValGluLys

Explanation / Answer

Glu-C: Met Gly Leu Ser Asp Trp Glu  

Glu-C: Ile Trp Gly His Val Asp Leu Pro Asn Glu

Glu-C: Ala Val Ile Arg Leu Tyr Glu

Chicken:Met Gly Leu Ser Asp Trp Glu Ile Trp Gly His Val Asp leu Pro Asn Glu Ala Val Ile Arg Leu Tyr Glu

Human: Met Gly Leu Ser Glu Trp Gln Leu Trp Gly Lys Val Glu Ile Pro Gln Glu Val Leu Ile Arg Leu Phe Glu Lys

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