EXTRA CREDIT CH.4 4 POINTS NAME 1) Tay-Sachs disease is a fatal genetic disorder

Question

EXTRA CREDIT CH.4 4 POINTS NAME 1) Tay-Sachs disease is a fatal genetic disorder that causes the brain and nerve cells to accumulate excessive amounts of specific lipids known as gangliosides. This abnormal accumulation of gangliosides leads to a progressive dysfunction of the central nervous system. Using your knowledge of the eukaryotie oells explains what is likely involved in this disease. structure of eukaryotic cells, identify the statement below that best A) The mitochondria are most likely defective and do not produce adequate amounts of ATP needed for cellular energy B) The rough endoplasmic reticulum contains too many ribosomes, which results in an overproduction of the enzyme involved in lipid breakdown. G) The lysosomes lack sufficient amounts of enzymes necessary for the metabolism of lipids. D) The Golg apparatus produces vesicles with faulty membranes, which fail to be transported to the plasma membrane for secretion. 2) The liver is involved in detoxification of many poisons and drugs. What structure is primarily involved in this process and, therefore, abundant in liver cells? 3) Radioactively labeled molecules can be used in many research experiments. In one experiment, plant seedlings were grown on a media containing labeled cytosine. In what three structures would you expect the radioactive cytosine to be found in the cells of the mature plants? (You must list all three correctly for credit.) 4) Latrunculin is a cytoskeletal drug that prevents polymerization od enhances depolymerization 4) of actin (microfilaments). A cell treated with latrunculin would still be able to A) perform amoeboid movement. B) form cleavage furrows. O ontract munclefhers D) extend pseudopodia. E) move vesicles around the cell In addition to determining the correct answer, write the type of cytoskeleton that is responsible for each of the above choices. (All parts of the question must be answered correctly for credit)

Explanation / Answer

Tay sacs desease caused by deficiency of beta hexosaminidase A is a lysosomal enzyme that normaly degrades GM2 gangliosides. It is an autosomal recessive disorder. Due to deficiency of beta hexosaminidase A,GM2 ganglioside accumulate in the lysosome and causes progressive damage of the nerve cell. Taysacs desease causing gene is located on the chromosome number 15.

So tthe answer (C) of question 1 is correct as the lysosomes lacks sufficient amount of enzymes necessory for the metabolism of lipids.

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