8. A friend of you telils you that thare is a genetic disorder that runs in his
ID: 144857 • Letter: 8
Question
8. A friend of you telils you that thare is a genetic disorder that runs in his family and he would he to know the probability that he is a camer, oven though he does not have the disor . He generation r. #5 in the pedigree below. Hint: first determine the mode of inertance, then figure out the probability that he is a carier iV a. 1/4 b. 1/2 c. 1/3 d. 2/3 e. None of the above 9. What is the probablity that if the affected male on the far left of generation IV has five children with a normal woman, 3 will be affected and 2 will be normal? d. e. 15/16 None of the above 10. You are studying fin formation in zebrafish and isolate two finless mutants, which do not have dorsal fins. For reasons we will not detail, you hypothesize that the mutation is recessive and 80% penetrant. To test your hypothesis, you cross the two finless animals and assay their progeny for the presence of a fin. Of 100 progeny, 10 are finless and 90 are wild-type. To determine if this difference between the expected and observed numbers is significant, calculate the chi-square value. a. 0.25 b. 1.25 c. 6.25 d. 10.25 e. None of the aboveExplanation / Answer
This is Autosomal recessive disorder. All the children of the original affected female were carriers. The first cousins in the consanguineous marriage in the third generation were also carriers, inheriting the recessive alleles from their carrier parents. The consanguineous marriage produced two affected children, one boy and one girl, and four unaffected children. In those unaffected children, the probability of being the carrier is 1/2.
Aa x Aa
Carrier x carrier
ANSWER. 2/4 or 1/2 -probability of being carrier(Aa)
1/4 -probability of being affected (aa)
1/4- probability of being unaffected (AA)
A a A AA Aa a Aa aaRelated Questions
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