Question 7, A phenotypically normal couple has a colorblind Klinefelter son (Xxy

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Question 7, A phenotypically normal couple has a colorblind Klinefelter son (Xxy). In which parent and at what meiotic stage must the non-disjunction event have occurred? A. Meiosis I of mother B. Meiosis I of father C. Meiosis II of father D. Meiosis II of mother E. Meiosis I or II of mother F. Meiosis I or II of father Question &, Nature of alleles. Learn the different genctic and molecular ways of classifying the various kinds of alleles that can arise due to mutations. For this information review Section 8.5 (6h Edition pages 299-303) and Table 82 (page 304). Which of the following types of alleles encode for proteins and which ones do not? Where genetic information for protein is encoded, what is the nature of the protein (dominant/recessive; loss-of -function, gain-of-function)? a. Amorphic; b. Hypomorphic; c. Hypermorphic; d. Antimorphic; e. Neomorphic. Question 9. (a) Why is the CF inherited in a recessive manner? (b) Why is HD inherited in a dominant manner? If you want to do more practice problems: For simple probability: Questions 10, 17, 24, 25 from your text book. Practice dihybrid crosses (self and test crosses) with questions 7, 8, 11, 29, 30, 31. For inheritance of dominant and recessive disease alleles, solve these problems: Questions 36-41 Study from answers in the solution manual (on blackboard)

Explanation / Answer

Ans 7.) option D is the correct answer. The non-disjunction occurs in the meiosis II of the mother. This non-disjunction occurs when the two sister chromatids X and X fails to separate during meiosis II and produces an egg having two X chromosomes. When this egg is fertilized with a Y sperm produces an offspring having Klinefelter syndrome (XXY).

Ans 8.) Amorphic allele: These are the allele which does not encode for proteins as they have eliminated gene activity and the nature of protein is recessive and there is a complete loss of function.

-Hypomorphic allele: These are the allele which encodes for a protein but they have reduced function of their gene. It also codes for the protein that is recessive and there is also a partial loss of function. The genetic information for protein is encoded in the cell's DNA.

-Hypermorphic allele: These alleles encode for the proteins and they are having increased gene activity. It codes for the protein that is dominant and having a gain of function.

-Antimorphic allele: These alleles codes for the protein and these alleles alters their gene activity to antagonize the activity of dominant proteins. These are having protein of dominant type and there is a gain of function.

-Neomorphic allele: These alleles also codes for the protein and having novel gene activity. These alleles encode for a dominant protein which is having a gain of function.

-All these protein information encoded by alleles done in the cell's DNA.

Ans 9) The CF is inherited in a recessive manner because both the parents are carriers of this disease and so two copies of recessive CFTR is required to cause the disease.

-The HD is inherited in a dominant manner because a change in one of the 2 copies of the HTT gene is enough to cause the disease.

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