Question 5 Shown on the right is the crystal structure of Pelota, an mRNA qualit

Question

Question 5 Shown on the right is the crystal structure of Pelota, an mRNA quality control factor that binds the ribosome when the ribosome is stalled (for example when elongation is blocked by strong secondary structure in the mRNA). Based on the structure shown and what was covered in class, answer the following questions: A- What RNA molecule does this factor resemble? B- Based on answer, where do you think this protein binds on the ribosome? Explain briefly C.) Pelota is also similar to which protein studied in class? (name one)-

Explanation / Answer

A-resembles the P site of tRna.

It carries the growing polypeptide chain

B- Pelota and its cofactors are involved in ribosome-associated quality control pathways that recognize stalled ribosome with an empty A site, to which Pelota binds and promotes ribosome subunit dissociation.

C- It resembles the RNA binding Sm and Lsm (Sm-like) proteins

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