A. A. Which statement regarding collagen is most TRUE? a. Collagen structure is

Question

A.

A. Which statement regarding collagen is most TRUE?

a. Collagen structure is based upon a coiled-coil.

b. Hydrogen bonds between collagen peptides occur between the lone pair on the peptide nitrogen and the hydrogen on the peptide carbonyl group.

c. The triple helix of collagen is stabilized through disulfide bonds.

d. Collagen contains Pro amino acids that are post-translationally modified.

B. Which of the following statements is most TRUE regarding the alpha helix of a protein in aqueous solution as represented by the hydropathy plot (helical wheel) shown below?

a. it lies on the surface of the protein with the right side exposed to the solvent and the left side facing the interior of the protein

b. it lies on the surface of the protein with the left side exposed to the solvent and the right side facing the interior of the protein

c. it protrudes on the outside of the protein into the solvent

d. it lies buried in the interior of the protein

Explanation / Answer

A- collagen structure is stabilized by H-bond, not by the disulphide linkage.

Collagen structure is made up of the triple helix which interwinds with the each other by H-bond.

Hydroxyl-proline is present in Collagen which is the modified from proline after translation.

In case of H bond, NH group is the Hydrogen donor and CO group is the Hydrogen acceptor.

SO correct answer is the option d. Collagen contains Pro amino acids that are post-translationally modified.

B-

In the given diagram, amino acids present at the right-hand side are polar or hydrophilic amino acid and at the left-hand side are non-polar or hydrophobic amino acids

When the protein is present in aqueous solution, due to polar nature the right-hand side will be facing the solvent and the left-hand side will be buried inside the protein.

So answer is option a. it lies on the surface of the protein with the right side exposed to the solvent and the left side facing the interior of the protein

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